Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells | Zendy

Adolf Michael Sandbichler | Zendy; Bianca Jansen | Zendy; Bettina A. Peer | Zendy; Monika Paulitsch | Zendy; Bernd Pelster | Zendy; Margit Egg | Zendy

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Metabolic Plasticity Enables Circadian Adaptation to Acute Hypoxia in Zebrafish Cells

Author(s) -

Adolf Michael Sandbichler,

Bianca Jansen,

Bettina A. Peer,

Monika Paulitsch,

Bernd Pelster,

Margit Egg

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000489058

Subject(s) - circadian rhythm , hypoxia (environmental) , biology , zebrafish , circadian clock , microbiology and biotechnology , glycolysis , medicine , endocrinology , biochemistry , metabolism , chemistry , gene , oxygen , organic chemistry

Reduced oxygen availability, hypoxia, is frequently encountered by organisms, tissues and cells, in aquatic environments as well as in high altitude or under pathological conditions such as infarct, stroke or cancer. The hypoxic signaling pathway was found to be mutually intertwined with circadian timekeeping in vertebrates and, as reported recently, also in mammals. However, the impact of hypoxia on intracellular metabolic oscillations is still unknown.

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