Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic Target | Zendy

Jinhua Chen | Zendy; Ying Chen | Zendy; Jiali Pu | Zendy

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Leucine-Rich Repeat Kinase 2 in Parkinson’s Disease: Updated from Pathogenesis to Potential Therapeutic Target

Author(s) -

Jinhua Chen,

Ying Chen,

Jiali Pu

Publication year - 2018

Publication title -

european neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.573

H-Index - 77

eISSN - 1421-9913

pISSN - 0014-3022

DOI - 10.1159/000488938

Subject(s) - lrrk2 , pathogenesis , parkinson's disease , pathophysiology , dopaminergic , medicine , kinase , disease , bioinformatics , biology , genetics , dopamine

Parkinson's disease (PD) is characterized by the selective loss of dopaminergic neurons in the midbrain. The pathogenesis of PD is not fully understood but is likely caused by a combination of genetic and environmental factors. Several genes are associated with the onset and progression of familial PD. There is increasing evidence that leucine-rich repeat kinase 2 (LRRK2) plays a significant role in PD pathophysiology.

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