Cinobufagin Induces Apoptosis in Osteosarcoma Cells Via the Mitochondria-Mediated Apoptotic Pathway | Zendy

Guo Dai | Zendy; Di Zheng | Zendy; Weichun Guo | Zendy; Jian Yang | Zendy; An-Yuan Cheng | Zendy

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Cinobufagin Induces Apoptosis in Osteosarcoma Cells Via the Mitochondria-Mediated Apoptotic Pathway

Author(s) -

Guo Dai,

Di Zheng,

Weichun Guo,

Jian Yang,

An-Yuan Cheng

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488842

Subject(s) - apoptosis , viability assay , clonogenic assay , annexin , cell growth , cancer research , biology , chemistry , microbiology and biotechnology , biochemistry

Osteosarcoma is a common primary malignant bone tumor that mainly occurs in childhood and adolescence. Despite developments in the diagnosis and treatment of osteosarcoma, the prognosis is still very poor. Cinobufagin is an active component in the anti-tumor Chinese medicine called "Chan Su", and we previously revealed that cinobufagin induced apoptosis and reduced the viability of osteosarcoma cells; however, the underlying mechanism remains to be elucidated. Herein, the present study was undertaken to illuminate the molecular mechanism of cinobufagin-induced apoptosis of osteosarcoma cell.

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