Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia | Zendy

Xuan Sheng | Zendy; Jiayue Wang | Zendy; Jingjing Guo | Zendy; Yurong Xu | Zendy; Huaide Jiang | Zendy; Chaoran Zheng | Zendy; Zixi Xu | Zendy; Yuanruohan Zhang | Zendy; Hongyu Che | Zendy; Shangdong Liang | Zendy; Gaochun Zhu | Zendy; Guilin Li | Zendy

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Effects of Baicalin on Diabetic Cardiac Autonomic Neuropathy Mediated by the P2Y12 Receptor in Rat Stellate Ganglia

Author(s) -

Xuan Sheng,

Jiayue Wang,

Jingjing Guo,

Yurong Xu,

Huaide Jiang,

Chaoran Zheng,

Zixi Xu,

Yuanruohan Zhang,

Hongyu Che,

Shangdong Liang,

Gaochun Zhu,

Guilin Li

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488828

Subject(s) - medicine , baicalin , receptor , cardiology , endocrinology , hepatic stellate cell , chemistry , high performance liquid chromatography , chromatography

Chronic diabetic hyperglycemia can damage various of organ systems and cause serious complications. Although diabetic cardiac autonomic neuropathy (DCAN) is the primary cause of death in diabetic patients, its pathogenesis remains to be fully elucidated. Baicalin is a flavonoid extracted from Scutellaria baicalensis root and has antibacterial, diuretic, anti-inflammatory, anti- metamorphotic, and antispasmodic effects. Our study explored the effects of baicalin on enhancing sympathoexcitatory response induced by DCAN via the P2Y12 receptor.

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