Bubbles Induce Endothelial Microparticle Formation via a Calcium-Dependent Pathway Involving Flippase Inactivation and Rho Kinase Activation | Zendy

Xuhua Yu | Zendy; Jiajun Xu | Zendy; Wenwu Liu | Zendy; Weigang Xu | Zendy

Open Access

Bubbles Induce Endothelial Microparticle Formation via a Calcium-Dependent Pathway Involving Flippase Inactivation and Rho Kinase Activation

Author(s) -

Xuhua Yu,

Jiajun Xu,

Wenwu Liu,

Weigang Xu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488825

Subject(s) - microbiology and biotechnology , flippase , phosphatidylserine , colocalization , actin , kinase , extracellular , phosphorylation , chemistry , calcium , myosin light chain kinase , biophysics , biology , biochemistry , phospholipid , organic chemistry , membrane

Intravascular bubbles can exert pleiotropic detrimental effects, partly by inducing endothelial microparticles (EMPs) production, which play critical roles in cell communication and vascular inflammation cascades. However, the underlying mechanisms remain unclear. This study aimed to delineate the possible mechanisms involving bubble-induced EMPs formation.

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