Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems | Zendy

Shihab Kochumon | Zendy; Ajit Wilson | Zendy; Betty Chandy | Zendy; Steve Shenouda | Zendy; Jaakko Tuomilehto | Zendy; Sardar Sindhu | Zendy; Rasheed Ahmad | Zendy

Open Access

Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems

Author(s) -

Shihab Kochumon,

Ajit Wilson,

Betty Chandy,

Steve Shenouda,

Jaakko Tuomilehto,

Sardar Sindhu,

Rasheed Ahmad

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488824

Subject(s) - ccl4 , chemokine , tlr4 , mapk/erk pathway , microbiology and biotechnology , ly294002 , inflammation , thp1 cell line , chemistry , biology , signal transduction , pi3k/akt/mtor pathway , cell culture , immunology , carbon tetrachloride , genetics , organic chemistry

Obesity is associated with adipose tissue inflammation which plays a key role in the development of insulin resistance and type 2 diabetes (T2D). Saturated free fatty acids (SFAs) levels are found to be elevated in obesity and T2D. Chemokines are known to have potent inflammatory functions in a wide range of biological processes linked to immunological disorders. Since CCL4 (Chemokine (C-C motif) ligand 4), also known as macrophage inflammatory protein-1β (MIP-1β), plays an important role in the migration of monocytes into the adipose tissue, we investigated the expression of CCL4 in monocytic cells/macrophages following activation with free fatty acid palmitate.

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