Autophagy Facilitates Metadherin-Induced Chemotherapy Resistance Through the AMPK/ATG5 Pathway in Gastric Cancer | Zendy

Guoqing Pei | Zendy; Meng Luo | Zendy; Xiaochun Ni | Zendy; Jugang Wu | Zendy; Shoulian Wang | Zendy; Yiwen Ma | Zendy; Jiwei Yu | Zendy

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Autophagy Facilitates Metadherin-Induced Chemotherapy Resistance Through the AMPK/ATG5 Pathway in Gastric Cancer

Author(s) -

Guoqing Pei,

Meng Luo,

Xiaochun Ni,

Jugang Wu,

Shoulian Wang,

Yiwen Ma,

Jiwei Yu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488742

Subject(s) - autophagy , atg5 , ampk , gene knockdown , cancer research , downregulation and upregulation , western blot , apoptosis , chemistry , biology , microbiology and biotechnology , phosphorylation , biochemistry , protein kinase a , gene

Metadherin (MTDH) is overexpressed in some malignancies and enhances drug resistance; however, its role in gastric cancer (GC) and the underlying mechanisms remain largely unexplored. Here, we explore the mechanism by which MTDH induces drug resistance in GC.

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