The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension | Zendy

Agnieszka Polak | Zendy; Ewa HarasimSymbor | Zendy; Barbara Malinowska | Zendy; Irena Kasacka | Zendy; Alicja Lewandowska | Zendy; Adrian Chabowski | Zendy

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The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension

Author(s) -

Agnieszka Polak,

Ewa HarasimSymbor,

Barbara Malinowska,

Irena Kasacka,

Alicja Lewandowska,

Adrian Chabowski

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488730

Subject(s) - medicine , endocrinology , glut4 , carbohydrate metabolism , glycogen , glut1 , glucose transporter , glycogen synthase , insulin , glucose uptake , glucose metabolism disorder , fatty acid amide hydrolase , chemistry , insulin resistance , cannabinoid receptor , receptor , antagonist

Recent interest in the use of cannabinoids as therapeutic agents has revealed the involvement of the endogenous cannabinoid system (ECS) in the regulation of the cardiovascular system in hypertension. Abnormalities in glucose metabolism and insulin action are commonly detected in hypertensive animals. Thus, potential antihypertensive drugs should be investigated with respect to modulation of glucose homeostasis. Therefore, the aim of the present study was to evaluate the effects of the ECS activation after chronic fatty acid amide hydrolase inhibitor (URB597) administration on plasma glucose and insulin concentrations as well as parameters of myocardial glucose metabolism in the deoxycorticosterone acetate (DOCA)-salt hypertensive rats, an animal model of secondary hypertension.

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