Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx | Zendy

Yingliang Wei | Zendy; Dianbin Zheng | Zendy; Xiaocheng Guo | Zendy; Min Zhao | Zendy; Linlin Gao | Zendy; Lunhao Bai | Zendy

Open Access

Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx

Author(s) -

Yingliang Wei,

Dianbin Zheng,

Xiaocheng Guo,

Min Zhao,

Linlin Gao,

Lunhao Bai

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488725

Subject(s) - transient receptor potential channel , trpv1 , apoptosis , osteoarthritis , chondrocyte , capsaicin , chemistry , mediation , receptor , medicine , microbiology and biotechnology , neuroscience , pharmacology , endocrinology , biology , anatomy , cartilage , biochemistry , pathology , alternative medicine , political science , law

Chondrocyte apoptosis is the most common pathological feature in cartilage in osteoarthritis (OA). Transient receptor potential channel vanilloid 5 (TRPV5) is important in regulating calcium ion (Ca2+) influx. Accumulating evidences suggest that Ca2+ is a major intracellular second messenger that can trigger cell apoptosis. Therefore, we investigate the potential role of TRPV5 in mediating Ca2+ influx to promote chondrocyte apoptosis in OA.

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