Open AccessTargeting mTOR by CZ415 Inhibits Head and Neck Squamous Cell Carcinoma Cells
Author(s) -
Jing Xie,
Quan Li,
Xi Ding,
Yunyun Gao
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000488724
Subject(s) - head and neck squamous cell carcinoma , cancer research , autophagy , pi3k/akt/mtor pathway , cell growth , mtorc1 , chemistry , mtt assay , apoptosis , cell culture , microbiology and biotechnology , biology , medicine , cancer , head and neck cancer , biochemistry , genetics
mTOR is an important therapeutic target for human head and neck squamous cell carcinoma (HNSCC). The current study tested the anti-HNSCC cell activity by a mTOR kinase inhibitor CZ415.
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