Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function | Zendy

Xiaotang Ma | Zendy; Jinju Wang | Zendy; Jiao Li | Zendy; Chunlian Ma | Zendy; Shuzhen Chen | Zendy; Wei Lei | Zendy; Yi Yang | Zendy; Shiming Liu | Zendy; Ji Bihl | Zendy; Can Chen | Zendy

Open Access

Loading MiR-210 in Endothelial Progenitor Cells Derived Exosomes Boosts Their Beneficial Effects on Hypoxia/Reoxygeneation-Injured Human Endothelial Cells via Protecting Mitochondrial Function

Author(s) -

Xiaotang Ma,

Jinju Wang,

Jiao Li,

Chunlian Ma,

Shuzhen Chen,

Wei Lei,

Yi Yang,

Shiming Liu,

Ji Bihl,

Can Chen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488635

Subject(s) - mfn2 , endothelial progenitor cell , mitochondrial fission , microbiology and biotechnology , apoptosis , viability assay , transfection , progenitor cell , dnm1l , angiogenesis , mitochondrial ros , microvesicles , reactive oxygen species , flow cytometry , mitochondrial fusion , biology , mitochondrion , chemistry , microrna , stem cell , cell culture , cancer research , biochemistry , mitochondrial dna , genetics , gene

Stem cell-derived exosomes (EXs) offer protective effects on various cells via their carried microRNAs (miRs). Meanwhile, miR-210 has been shown to reduce mitochondrial reactive oxygen species (ROS) overproduction. In this study, we determined the potential effects of endothelial progenitor cell-derived EXs (EPC-EXs) on hypoxia/ reoxygenation (H/R) injured endothelial cells (ECs) and investigated whether these effects could be boosted by miR-210 loading.

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