DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis | Zendy

Yan Ding | Zendy; Lanlan Shan | Zendy; Wenqing Nai | Zendy; Xiaojun Lin | Zendy; Ling Zhou | Zendy; Xiaoying Dong | Zendy; Hongyuan Wu | Zendy; Min Xiao | Zendy; Xuejuan Zhou | Zendy; Linlin Wang | Zendy; Ting Li | Zendy; You Fu | Zendy; Yijun Lin | Zendy; Chunhong Jia | Zendy; Meng Dai | Zendy; Xiaochun Bai | Zendy

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DEPTOR Deficiency-Mediated mTORc1 Hyperactivation in Vascular Endothelial Cells Promotes Angiogenesis

Author(s) -

Yan Ding,

Lanlan Shan,

Wenqing Nai,

Xiaojun Lin,

Ling Zhou,

Xiaoying Dong,

Hongyuan Wu,

Min Xiao,

Xuejuan Zhou,

Linlin Wang,

Ting Li,

You Fu,

Yijun Lin,

Chunhong Jia,

Meng Dai,

Xiaochun Bai

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488619

Subject(s) - angiogenesis , cd31 , pi3k/akt/mtor pathway , vascular endothelial growth factor , mtorc1 , microbiology and biotechnology , cancer research , gene knockdown , biology , vascular endothelial growth factor a , signal transduction , cell culture , genetics , vegf receptors

The mechanistic target of rapamycin (mTOR) signaling pathway is essential for angiogenesis and embryonic development. DEP domain-containing mTOR-interacting protein (DEPTOR) is an mTOR binding protein that functions to inhibit the mTOR pathway In vitro experiments suggest that DEPTOR is crucial for vascular endothelial cell (EC) activation and angiogenic responses. However, knowledge of the effects of DEPTOR on angiogenesis in vivo is limited. This study aimed to determine the role of DEPTOR in tissue angiogenesis and to elucidate the molecular mechanisms.

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