Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2 | Zendy

Fang-Fang He | Zendy; Ren-Yu You | Zendy; Chen Ye | Zendy; ChunTao Lei | Zendy; Hui Tang | Zendy; Hua Su | Zendy; Chun Zhang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Inhibition of SIRT2 Alleviates Fibroblast Activation and Renal Tubulointerstitial Fibrosis via MDM2

Author(s) -

Fang-Fang He,

Ren-Yu You,

Chen Ye,

ChunTao Lei,

Hui Tang,

Hua Su,

Chun Zhang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488613

Subject(s) - sirt2 , western blot , gene knockdown , fibroblast , downregulation and upregulation , cancer research , chemistry , sirtuin , microbiology and biotechnology , biology , nad+ kinase , apoptosis , biochemistry , in vitro , gene , enzyme

Renal tubular epithelial cells and fibroblasts are the main sources of myofibroblasts, and these cells produce the extracellular matrix during tubulointerstitial fibrosis (TIF). Histone deacetylases (HDAC) inhibitors exert an antifibrogenic effect in the skin, liver and lung. Sirtuin 2 (SIRT2), which is a class III HDAC, is an important member of NAD+-dependent protein deacetylases. The current study evaluated the role of SIRT2 in renal TIF.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research