Characterization of Hepatocellular Carcinoma Patients with FGF19 Amplification Assessed by Fluorescence in situ Hybridization: A Large Cohort Study | Zendy

Hyo Jeong Kang | Zendy; Farhan Haq | Zendy; Chang Ohk Sung | Zendy; Jene Choi | Zendy; SeungMo Hong | Zendy; SooHeang Eo | Zendy; Hui Jeong Jeong | Zendy; Jin-Ho Shin | Zendy; Ju Hyun Shim | Zendy; Han Chu Lee | Zendy; Jihyun An | Zendy; MiJu Kim | Zendy; Kyupyo Kim | Zendy; SungMin Ahn | Zendy; Eunsil Yu | Zendy

Open Access

Characterization of Hepatocellular Carcinoma Patients with <b><i>FGF19</i></b> Amplification Assessed by Fluorescence in situ Hybridization: A Large Cohort Study

Author(s) -

Hyo Jeong Kang,

Farhan Haq,

Chang Ohk Sung,

Jene Choi,

SeungMo Hong,

SooHeang Eo,

Hui Jeong Jeong,

Jin-Ho Shin,

Ju Hyun Shim,

Han Chu Lee,

Jihyun An,

MiJu Kim,

Kyupyo Kim,

SungMin Ahn,

Eunsil Yu

Publication year - 2018

Publication title -

liver cancer

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.916

H-Index - 34

eISSN - 2235-1795

pISSN - 1664-5553

DOI - 10.1159/000488541

Subject(s) - fgf19 , fluorescence in situ hybridization , hepatocellular carcinoma , in situ hybridization , immunohistochemistry , medicine , hepatitis b virus , cancer research , pathology , biology , oncology , gene , gene expression , immunology , fibroblast growth factor , virus , receptor , genetics , chromosome

FGF19 amplification is a relatively novel type of genetic aberration that has been proposed to be a driver of hepatocarcinogenesis. Selective inhibitors of FGFR4 , a receptor of FGF19 , have been developed as targeted therapies for hepatocellular carcinoma (HCC). Despite the role of FGF19 in mediating HCC progression, the clinicopathological characterization of patients exhibiting FGF19 amplification remains unclear. Immunohistochemical staining is the simplest and most widely used method of identifying aberrations in the FGF19 gene, although its specificity is very low.

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