Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men | Zendy

Ali Abbara | Zendy; Shakunthala Narayanaswamy | Zendy; Chioma IzziEngbeaya | Zendy; Alexander Comninos | Zendy; Sophie Clarke | Zendy; Zainab Malik | Zendy; Deborah Papadopoulou | Zendy; Ailish Clobentz | Zendy; Zubair Sarang | Zendy; Paul Bassett | Zendy; Chan. Jayasena | Zendy; Waljit S. Dhillo | Zendy

Open Access

Hypothalamic Response to Kisspeptin-54 and Pituitary Response to Gonadotropin-Releasing Hormone Are Preserved in Healthy Older Men

Author(s) -

Ali Abbara,

Shakunthala Narayanaswamy,

Chioma IzziEngbeaya,

Alexander Comninos,

Sophie Clarke,

Zainab Malik,

Deborah Papadopoulou,

Ailish Clobentz,

Zubair Sarang,

Paul Bassett,

Chan. Jayasena,

Waljit S. Dhillo

Publication year - 2018

Publication title -

neuroendocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.493

H-Index - 101

eISSN - 1423-0194

pISSN - 0028-3835

DOI - 10.1159/000488452

Subject(s) - kisspeptin , medicine , endocrinology , gonadotropin , testosterone (patch) , gonadotropin releasing hormone , hormone , luteinizing hormone

Male testosterone levels decline by 1% per year from the age of 40 years. Whilst a primary testicular deficit occurs, hypothalamic or pituitary dysregulation may also coexist. This study aimed to compare the hypothalamic response to kisspeptin-54 and the pituitary response to gonadotropin-releasing hormone (GnRH) of older men with those of young men.

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