Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet β-Cell Function | Zendy

Yuting Ruan | Zendy; Nie Lin | Zendy; Qiang Ma | Zendy; Rongping Chen | Zendy; Zhen Zhang | Zendy; Weiheng Wen | Zendy; Hong Chen | Zendy; Jia Sun | Zendy

Open Access

Circulating LncRNAs Analysis in Patients with Type 2 Diabetes Reveals Novel Genes Influencing Glucose Metabolism and Islet β-Cell Function

Author(s) -

Yuting Ruan,

Nie Lin,

Qiang Ma,

Rongping Chen,

Zhen Zhang,

Weiheng Wen,

Hong Chen,

Jia Sun

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488434

Subject(s) - biology , endocrinology , insulin , islet , medicine , type 2 diabetes , carbohydrate metabolism , gene knockdown , microvesicles , glut2 , diabetes mellitus , long non coding rna , pancreatic islets , apoptosis , microrna , downregulation and upregulation , gene , glucose transporter , biochemistry

The islet is an important endocrine organ to secrete insulin to regulate the metabolism of glucose and maintain the stability of blood glucose. Long noncoding RNAs (lncRNAs) are involved in a variety of biological functions and play key roles in many diseases, including type 2 diabetes (T2D). The aim of this study was to determine whether lncRNA-p3134 is associated with glucose metabolism and insulin signaling in pancreatic β cells.

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