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Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine
Author(s) -
Chuandong Wang,
Fei Xiao,
Yaokai Gan,
Weien Yuan,
Zhanjing Zhai,
Tuo Jin,
Xiaohong Chen,
Xiaoling Zhang
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000488416
Subject(s) - chordin , nonunion , gene knockdown , gene silencing , microbiology and biotechnology , bone morphogenetic protein 7 , noggin , bone morphogenetic protein 2 , bone morphogenetic protein , chemistry , in vitro , biology , anatomy , apoptosis , gene , biochemistry
Bone nonunion remains a challenge for orthopaedists. The technological advancements that have been made in precisely silencing target genes have provided promising methods to address this challenge.

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