Overexpression of PTPN2 in Visceral Adipose Tissue Ameliorated Atherosclerosis via T Cells Polarization Shift in Diabetic Apoe-/- Mice | Zendy

LI Ya | Zendy; Huimin Zhou | Zendy; Rui Wang | Zendy; Lu Han | Zendy; Minghao Liu | Zendy; Yihui Li | Zendy; Zhihao Wang | Zendy; Mengxiong Tang | Zendy; Wei Zhang | Zendy; Ming Zhong | Zendy

Open Access

Overexpression of PTPN2 in Visceral Adipose Tissue Ameliorated Atherosclerosis via T Cells Polarization Shift in Diabetic Apoe-/- Mice

Author(s) -

LI Ya,

Huimin Zhou,

Rui Wang,

Lu Han,

Minghao Liu,

Yihui Li,

Zhihao Wang,

Mengxiong Tang,

Wei Zhang,

Ming Zhong

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488415

Subject(s) - medicine , endocrinology , insulin resistance , white adipose tissue , inflammation , adipose tissue , adipose tissue macrophages , macrophage polarization , streptozotocin , diabetes mellitus , chemistry , macrophage , in vitro , biochemistry

Dysregulated inflammation in adipose tissue, marked by increased pro-inflammatory T-cell accumulation and reduced regulatory T cells (Treg), contributes to diabetes-associated insulin resistance and atherosclerosis. However, the molecular mechanisms underlying T-cell-mediated inflammation in adipose tissue remain largely unknown.

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