MicroRNA-183 Acts as a Tumor Suppressor in Human Non-Small Cell Lung Cancer by Down-Regulating MTA1
Author(s) -
Chengliang Yang,
Xiaoli Zheng,
Ke Ye,
Hong Ge,
Yanan Sun,
Yufei Lu,
Qingxia Fan
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000488412
Subject(s) - vimentin , microrna , biology , flow cytometry , cancer research , apoptosis , proliferating cell nuclear antigen , cell growth , epithelial–mesenchymal transition , transfection , immunohistochemistry , western blot , microbiology and biotechnology , cancer , cell culture , metastasis , immunology , gene , biochemistry , genetics
MicroRNAs (miRs) often contribute to the progression of non-small cell lung cancer (NSCLC) via regulation of mRNAs that are involved in lung homeostasis. We conducted a study aimed at exploring the roles of miR-183 in the proliferation, epithelial-mesenchymal transition (EMT), invasion and migration of human NSCLC cells via targeting MTA1.
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