MicroRNA-30a Suppresses the Activation of Hepatic Stellate Cells by Inhibiting Epithelial-to-Mesenchymal Transition | Zendy

Jianjian Zheng | Zendy; Wei Wang | Zendy; Fujun Yu | Zendy; Peihong Dong | Zendy; Bicheng Chen | Zendy; Mengtao Zhou | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

MicroRNA-30a Suppresses the Activation of Hepatic Stellate Cells by Inhibiting Epithelial-to-Mesenchymal Transition

Author(s) -

Jianjian Zheng,

Wei Wang,

Fujun Yu,

Peihong Dong,

Bicheng Chen,

Mengtao Zhou

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000488411

Subject(s) - snai1 , epithelial–mesenchymal transition , hepatic stellate cell , microrna , cancer research , vimentin , ccl4 , fibrosis , hepatic fibrosis , downregulation and upregulation , chemistry , biology , microbiology and biotechnology , pathology , immunology , endocrinology , medicine , carbon tetrachloride , gene , immunohistochemistry , biochemistry , organic chemistry

The activation of hepatic stellate cells (HSCs) is considered as a pivotal event in liver fibrosis and epithelial-mesenchymal transition (EMT) process has been reported to be involved in HSC activation. It is known that microRNAs (miRNAs) play a pro-fibrotic or anti-fibrotic role in HSC activation. Recently, emerging studies show that miR-30a is down-regulated in human cancers and over-expression of miR-30a inhibits tumor growth and invasion via suppressing EMT process. However, whether miR-30a could regulate EMT process in HSC activation is still unclear.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research