Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways | Zendy

Xuelian Li | Zendy; GuoYuan Wang | Zendy; MuGe QiLi | Zendy; Haihai Liang | Zendy; Tianshi Li | Zendy; E Xiaoqiang | Zendy; Ying Feng | Zendy; Ying Zhang | Zendy; Xiao Liu | Zendy; Ming Qian | Zendy; Bozhi Xu | Zendy; Zhihang Shen | Zendy; Samuel Chege Gitau | Zendy; Dandan Zhao | Zendy; Hongli Shan | Zendy

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Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways

Author(s) -

Xuelian Li,

GuoYuan Wang,

MuGe QiLi,

Haihai Liang,

Tianshi Li,

E Xiaoqiang,

Ying Feng,

Ying Zhang,

Xiao Liu,

Ming Qian,

Bozhi Xu,

Zhihang Shen,

Samuel Chege Gitau,

Dandan Zhao,

Hongli Shan

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487972

Subject(s) - aspirin , medicine , cardiac fibrosis , fibrosis , protein kinase b , endocrinology , pharmacology , chemistry , phosphorylation , biochemistry

Cardiac interstitial fibrosis is an abnormality of various cardiovascular diseases, including myocardial infarction, hypertrophy, and atrial fibrillation, and it can ultimately lead to heart failure. However, there is a lack of practical therapeutic approaches to treat fibrosis and reverse the damage to the heart. The purpose of this study was to investigate the effect of long-term aspirin administration on pressure overload-induced cardiac fibrosis in mice and reveal the underlying mechanisms of aspirin treatment.

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