Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy | Zendy

Ji Tu | Zendy; Wentian Li | Zendy; Shuai Li | Zendy; Wei Liu | Zendy; Yukun Zhang | Zendy; Xinghuo Wu | Zendy; Rongjin Luo | Zendy; Wenbin Hua | Zendy; Kun Wang | Zendy; Yu Song | Zendy; Liang Kang | Zendy; Wen Jiu Yang | Zendy; Shuhua Yang | Zendy; Yang Cao | Zendy

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Sestrin-Mediated Inhibition of Stress-Induced Intervertebral Disc Degradation Through the Enhancement of Autophagy

Author(s) -

Ji Tu,

Wentian Li,

Shuai Li,

Wei Liu,

Yukun Zhang,

Xinghuo Wu,

Rongjin Luo,

Wenbin Hua,

Kun Wang,

Yu Song,

Liang Kang,

Wen Jiu Yang,

Shuhua Yang,

Yang Cao

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487970

Subject(s) - autophagy , microbiology and biotechnology , intervertebral disc , chemistry , stress (linguistics) , biophysics , medicine , apoptosis , biology , biochemistry , anatomy , linguistics , philosophy

Intervertebral disc degeneration (IDD) is a pathological process that is the primary cause of low back pain and is potentially mediated by compromised stress defense. Sestrins (Sesn) promote cell survival under stress conditions and regulate AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signaling. Here, we investigated the expression of Sesn in normal and degraded nucleus pulposus (NP) cells and its potential roles during IDD pathogenesis.

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