MicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells | Zendy

Xavier VidalGómez | Zendy; Daniel PérezCremades | Zendy; Ana Mompeón | Zendy; Ana Paula Dantas | Zendy; Susaovella | Zendy; Carlos Hermenegildo | Zendy

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MicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells

Author(s) -

Xavier VidalGómez,

Daniel PérezCremades,

Ana Mompeón,

Ana Paula Dantas,

Susaovella,

Carlos Hermenegildo

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487910

Subject(s) - microrna , biology , estrogen receptor , microbiology and biotechnology , gper , estrogen receptor alpha , estrogen receptor beta , regulation of gene expression , microarray analysis techniques , in silico , estrogen , gene expression , gene , endocrinology , genetics , cancer , breast cancer

Estrogen signalling plays an important role in vascular biology as it modulates vasoactive and metabolic pathways in endothelial cells. Growing evidence has also established microRNA (miRNA) as key regulators of endothelial function. Nonetheless, the role of estrogen regulation on miRNA profile in endothelial cells is poorly understood. In this study, we aimed to determine how estrogen modulates miRNA profile in human endothelial cells and to explore the role of the different estrogen receptors (ERα, ERβ and GPER) in the regulation of miRNA expression by estrogen.

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