Knockdown of Bone Morphogenetic Proteins Type 1a Receptor (BMPR1a) in Breast Cancer Cells Protects Bone from Breast Cancer-Induced Osteolysis by Suppressing RANKL Expression | Zendy

Yang Liu | Zendy; Ranxi Zhang | Zendy; Wei Yuan | Zendy; Hou-Qing Chen | Zendy; Dongdong Tian | Zendy; Hao Li | Zendy; Xiao Jiang | Zendy; Zhongliang Deng | Zendy; Yang Wang | Zendy

Open Access

Knockdown of Bone Morphogenetic Proteins Type 1a Receptor (BMPR1a) in Breast Cancer Cells Protects Bone from Breast Cancer-Induced Osteolysis by Suppressing RANKL Expression

Author(s) -

Yang Liu,

Ranxi Zhang,

Wei Yuan,

Hou-Qing Chen,

Dongdong Tian,

Hao Li,

Xiao Jiang,

Zhongliang Deng,

Yang Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487784

Subject(s) - rankl , cancer research , gene knockdown , osteoclast , cancer cell , bone morphogenetic protein receptor , bone morphogenetic protein , stromal cell , breast cancer , bone metastasis , chemistry , metastasis , cancer , bone marrow , biology , medicine , pathology , receptor , apoptosis , activator (genetics) , biochemistry , gene

Bone morphogenetic proteins (BMPs) and BMP receptors widely participate in osteolytic metastasis of breast cancer, while their role in tumor-stromal interaction is largely unknown. In this study, we investigated whether BMP receptor type 1a (BMPR1a) can alter the interaction between metastatic cancer cells and osteoclast precursors.

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