A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia | Zendy

Fang Li | Zendy; Xiaoxue Fan | Zendy; Chun Chu | Zendy; Yu Zhang | Zendy; Junping Kou | Zendy; Boyang Yu | Zendy

Open Access

A Strategy for Optimizing the Combination of Active Components Based on Chinese Medicinal Formula Sheng-Mai-San for Myocardial Ischemia

Author(s) -

Fang Li,

Xiaoxue Fan,

Chun Chu,

Yu Zhang,

Junping Kou,

Boyang Yu

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487572

Subject(s) - medicine , ischemia , in vivo , traditional chinese medicine , cardioprotection , myocardial infarction , pharmacology , myocardial ischemia , combination therapy , cardiology , pathology , alternative medicine , microbiology and biotechnology , biology

Traditional Chinese medicine (TCM) has been used in clinical practice for thousands of years and has accumulated considerable knowledge concerning the in vivo efficacy of targeting complicated diseases. TCM formulae are a mixture of hundreds of chemical components with multiple potential targets, essentially acting as a combination therapy of multi-component drugs. However, the obscure substances and the unclear molecular mechanisms are obstacles to their further development and internationalization. Therefore, it is necessary to develop new modern drugs based on the combination of effective components in TCM with exact clinical efficacy. In present study, we aimed to detect optimal ratio of the combination of effective components based on Sheng-Mai-San for myocardial ischemia.

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