Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice | Zendy

Wenjing Liang | Zendy; Qian Wang | Zendy; Hui Ma | Zendy; Wenjiang Yan | Zendy; Jingjing Yang | Zendy

Open Access

Knockout of Low Molecular Weight FGF2 Attenuates Atherosclerosis by Reducing Macrophage Infiltration and Oxidative Stress in Mice

Author(s) -

Wenjing Liang,

Qian Wang,

Hui Ma,

Wenjiang Yan,

Jingjing Yang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487569

Subject(s) - oxidative stress , knockout mouse , adventitia , apolipoprotein e , fibroblast growth factor , endocrinology , medicine , angiogenesis , inflammation , macrophage , infiltration (hvac) , chemistry , biochemistry , receptor , disease , in vitro , physics , thermodynamics

Fibroblast growth factor 2 (FGF2) plays a predominant role during angiogenesis in the adventitia and in atherosclerotic plaque. A dilemma exists, however, as to whether angiogenic stimulation by FGF2 for the prevention and treatment of atherogenesis is feasible. The aim of this study is to investigate the effect of the 18-kDa FGF-2 isoform on atherosclerosis progression in high-fat diet-fed apolipoprotein E knockout (ApoE-/-) mice.

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