Functional SNP in the 3’UTR of PON1 is Associated with the Risk of Calcific Aortic Valve Stenosis via MiR-616 | Zendy

Zhengjun Wang | Zendy; Shiqiao Chen | Zendy; Mei Zhu | Zendy; Wenlong Zhang | Zendy; Haizhou Zhang | Zendy; Hongxin Li | Zendy; Chengwei Zou | Zendy

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Functional SNP in the 3’UTR of PON1 is Associated with the Risk of Calcific Aortic Valve Stenosis via MiR-616

Author(s) -

Zhengjun Wang,

Shiqiao Chen,

Mei Zhu,

Wenlong Zhang,

Haizhou Zhang,

Hongxin Li,

Chengwei Zou

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487565

Subject(s) - pon1 , snp , single nucleotide polymorphism , paraoxonase , medicine , genotype , biology , cardiology , endocrinology , gene , genetics , oxidative stress

Previous studies have examined the associations between the single nucleotide polymorphism in the Paraoxonase 1 (PON1) gene and development of calcific aortic valve stenosis (CAVS). The association between functional SNP in 3'UTR of PON1 and the risk of CAVS, however, is unclear. In this study, we investigated the role of SNP in the regulation of PON1 expression via miR-616, as well as the association of SNP with the risk of CAVS.

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