Low-Intensity Pulsed Ultrasound Prevents the Oxidative Stress Induced Endothelial-Mesenchymal Transition in Human Aortic Endothelial Cells | Zendy

Jiamin Li | Zendy; QingWei Zhang | Zendy; Cong Ren | Zendy; Xianxian Wu | Zendy; Ying Zhang | Zendy; Xue Bai | Zendy; Lin Yuan | Zendy; Mingqi Li | Zendy; Jiangbo Fu | Zendy; F. Yu. Kopylov | Zendy; Siqi Wang | Zendy; Tingting Yu | Zendy; Ning Wang | Zendy; Chaoqian Xu | Zendy; Yong Zhang | Zendy; Baofeng Yang | Zendy

Open Access

Low-Intensity Pulsed Ultrasound Prevents the Oxidative Stress Induced Endothelial-Mesenchymal Transition in Human Aortic Endothelial Cells

Author(s) -

Jiamin Li,

QingWei Zhang,

Cong Ren,

Xianxian Wu,

Ying Zhang,

Xue Bai,

Lin Yuan,

Mingqi Li,

Jiangbo Fu,

F. Yu. Kopylov,

Siqi Wang,

Tingting Yu,

Ning Wang,

Chaoqian Xu,

Yong Zhang,

Baofeng Yang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487561

Subject(s) - mesenchymal stem cell , oxidative stress , microbiology and biotechnology , pi3k/akt/mtor pathway , endothelial stem cell , extracellular matrix , protein kinase b , chemistry , wound healing , cancer research , immunology , signal transduction , medicine , biology , biochemistry , in vitro

Endothelial-mesenchymal transition (EndMT) has been shown to take part in the generation and progression of diverse diseases, involving a series of changes leading to a loss of their endothelial characteristics and an acquirement of properties typical of mesenchymal cells. Low-intensity pulsed ultrasound (LIPUS) is a new therapeutic option that has been successfully used in fracture healing. However, whether LIPUS can inhibit oxidative stress-induced endothelial cell damages through inhibiting EndMT remained unknown. This study aimed to investigate the protective effects of LIPUS against oxidative stress-induced endothelial cell damages and the underlying mechanisms.

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