Open AccessKnockdown of MAGEA6 Activates AMP-Activated Protein Kinase (AMPK) Signaling to Inhibit Human Renal Cell Carcinoma Cells
Author(s) -
Xueting Ye,
Jing Xie,
Hang Huang,
Zhexian Deng
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000487452
Subject(s) - ampk , gene knockdown , small hairpin rna , mtorc1 , cancer research , apoptosis , cell growth , protein kinase a , mtt assay , microbiology and biotechnology , biology , chemistry , pi3k/akt/mtor pathway , signal transduction , kinase , biochemistry
Melanoma antigen A6 (MAGEA6) is a cancer-specific ubiquitin ligase of AMP-activated protein kinase (AMPK). The current study tested MAGEA6 expression and potential function in renal cell carcinoma (RCC).
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