Inhibition of Suicidal Erythrocyte Death by Indirubin-3’-Monoxime | Zendy

Chunqiu Liu | Zendy; Peipei Jiang | Zendy; Yuanhong Xu | Zendy; Meijuan Zheng | Zendy; Jinpin Qiao | Zendy; Xueyong Zhou | Zendy; Dake Huang | Zendy; Maohong Bian | Zendy

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Inhibition of Suicidal Erythrocyte Death by Indirubin-3’-Monoxime

Author(s) -

Chunqiu Liu,

Peipei Jiang,

Yuanhong Xu,

Meijuan Zheng,

Jinpin Qiao,

Xueyong Zhou,

Dake Huang,

Maohong Bian

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487352

Subject(s) - phosphatidylserine , oxidative stress , chemistry , ionomycin , alexa fluor , flow cytometry , fluorescein isothiocyanate , reactive oxygen species , annexin , ceramide , apoptosis , cytosol , biochemistry , microbiology and biotechnology , biophysics , fluorescence , intracellular , biology , phospholipid , physics , quantum mechanics , membrane , enzyme

Qing Dai is a prized traditional Chinese medicine whose major component, indirubin, and its derivative, indirubin-3'-monoxime (IDM), have inhibitory effects on the growth of many human tumor cells and pronounced anti-leukemic activities. However, the effects of IDM on mature human erythrocytes are unclear. This study aimed to evaluate the potential impact of IDM on erythrocytes and the mechanisms underlying that impact.

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