Co-Upregulation of 14-3-3ζ and P-Akt is Associated with Oncogenesis and Recurrence of Hepatocellular Carcinoma
Author(s) -
Yufu Tang,
Ruoyu Wang,
Yibing Zhang,
Shenhui Lin,
Na Qiao,
Zhongyi Sun,
Shuqun Cheng,
Wenping Zhou
Publication year - 2018
Publication title -
cellular physiology and biochemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.486
H-Index - 87
eISSN - 1421-9778
pISSN - 1015-8987
DOI - 10.1159/000487351
Subject(s) - hepatocellular carcinoma , protein kinase b , carcinogenesis , medicine , concomitant , pi3k/akt/mtor pathway , proportional hazards model , downregulation and upregulation , hazard ratio , cancer research , oncology , gastroenterology , pathology , cancer , biology , apoptosis , confidence interval , gene , biochemistry
14-3-3ζ is involved in the regulation of PI3K/Akt pathway which is closely associated with carcinogenesis. However, the clinical significance of combined detection of 14-3-3ζ and p-Akt in hepatocellular carcinoma (HCC) remains unclear.
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