Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons | Zendy

Mengwen Qi | Zendy; Chunfeng Wu | Zendy; Zhouqing Wang | Zendy; Li Zhou | Zendy; Chen Men | Zendy; Yimei Du | Zendy; Songming Huang | Zendy; Lei Chen | Zendy; Ling Chen | Zendy

Open Access

Transient Receptor Potential Vanilloid 4 Activation-Induced Increase in Glycine-Activated Current in Mouse Hippocampal Pyramidal Neurons

Author(s) -

Mengwen Qi,

Chunfeng Wu,

Zhouqing Wang,

Li Zhou,

Chen Men,

Yimei Du,

Songming Huang,

Lei Chen,

Ling Chen

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487350

Subject(s) - chemistry , glycine receptor , agonist , protein kinase c , patch clamp , microbiology and biotechnology , transient receptor potential channel , protein kinase a , ion channel , pharmacology , receptor , biochemistry , signal transduction , glycine , kinase , biology , amino acid

Glycine plays an important role in regulating hippocampal inhibitory/ excitatory neurotransmission through activating glycine receptors (GlyRs) and acting as a co-agonist of N-methyl-d-aspartate-type glutamate receptors. Activation of transient receptor potential vanilloid 4 (TRPV4) is reported to inhibit hippocampal A-type γ-aminobutyric acid receptor, a ligand-gated chloride ion channel. GlyRs are also ligand-gated chloride ion channels and this paper aimed to explore whether activation of TRPV4 could modulate GlyRs.

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