Open AccessDoes Dietary Provision of Guanidinoacetic Acid Induce Global DNA Hypomethylation in Healthy Men and Women?
Author(s) -
Sergej M. Ostojić,
Marija Mojsin,
Patrik Drid,
Milan Vraneš
Publication year - 2018
Publication title -
lifestyle genomics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.542
H-Index - 30
eISSN - 2504-3188
pISSN - 2504-3161
DOI - 10.1159/000487336
Subject(s) - dna methylation , methylation , epigenetics , dna , medicine , endocrinology , chemistry , zoology , biology , biochemistry , gene expression , gene
Guanidinoacetic acid (GAA) is an experimental dietary additive and has been reported to induce methyl depletion when provided by the diet. However, no study evaluated whether supplemental GAA affects DNA methylation, a critical epigenetic process for genome regulation.
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