Down-Regulation of Neuropathy Target Esterase in Preeclampsia Placenta Inhibits Human Trophoblast Cell Invasion via Modulating MMP-9 Levels | Zendy

Ting Zhong | Zendy; Jiaxiang Chen | Zendy; Yan Ling | Zendy; Bei Yang | Zendy; Xingxing Xie | Zendy; Dainan Yu | Zendy; Dalei Zhang | Zendy; Jiexiu Ouyang | Zendy; Haibin Kuang | Zendy

Open Access

Down-Regulation of Neuropathy Target Esterase in Preeclampsia Placenta Inhibits Human Trophoblast Cell Invasion via Modulating MMP-9 Levels

Author(s) -

Ting Zhong,

Jiaxiang Chen,

Yan Ling,

Bei Yang,

Xingxing Xie,

Dainan Yu,

Dalei Zhang,

Jiexiu Ouyang,

Haibin Kuang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487296

Subject(s) - trophoblast , preeclampsia , placenta , matrix metalloproteinase , placentation , transfection , cell migration , microbiology and biotechnology , biology , chemistry , andrology , medicine , endocrinology , cell , cell culture , fetus , pregnancy , biochemistry , genetics

Neuropathy target esterase (NTE, also known as neurotoxic esterase) is proven to deacylate phosphatidylcholine (PC) to glycerophosphocholine as a phospholipase B. Recently; studies showed that artificial phosphatidylserine/PC microvesicles can induce preeclampsia (PE)-like changes in pregnant mice. However, it is unclear whether NTE plays a key role in the pathology of PE, a pregnancy-related disease, which was characterized by deficient trophoblast invasion and reduced trophoblast-mediated remodeling of spiral arteries. The aim of this study was to investigate the expression pattern of NTE in the placenta from women with PE and normal pregnancy, and the molecular mechanism of NTE involved in the development of PE.

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