ITRAQ-Based Proteomics Analysis of Triptolide On Human A549 Lung Adenocarcinoma Cells | Zendy

Fangqiong Li | Zendy; Dong-Xiao Zhao | Zendy; Suwen Yang | Zendy; Juan Wang | Zendy; Qin Liu | Zendy; Xin Jin | Zendy; Wei Wang | Zendy

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ITRAQ-Based Proteomics Analysis of Triptolide On Human A549 Lung Adenocarcinoma Cells

Author(s) -

Fangqiong Li,

Dong-Xiao Zhao,

Suwen Yang,

Juan Wang,

Qin Liu,

Xin Jin,

Wei Wang

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487286

Subject(s) - triptolide , kegg , a549 cell , apoptosis , cell cycle , cancer research , proteomics , biology , cancer cell , chemistry , microbiology and biotechnology , cancer , biochemistry , gene expression , gene , transcriptome , genetics

Triptolide (TP) is a diterpenoid triepoxide extracted from the traditional Chinese medical herb Tripterygium wilfordii that exerts prominent broad-spectrum anticancer activity to repress proliferation and induce cancer cell apoptosis through various molecular pathways. We previously observed that TP inhibits the progression of A549 cells and pancreatic cancer cells (PNCA-1) in vitro. However, the complex molecular mechanism underlying the anticancer activity of TP is not well understood.

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