Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins | Zendy

Nattayaporn Apaiajai | Zendy; Titikorn Chunchai | Zendy; Thidarat Jaiwongkam | Zendy; Sasiwan Kerdphoo | Zendy; Siriporn C. Chattipakorn | Zendy; Nipon Chattipakorn | Zendy

Open Access

Testosterone Deprivation Aggravates Left-Ventricular Dysfunction in Male Obese Insulin-Resistant Rats via Impairing Cardiac Mitochondrial Function and Dynamics Proteins

Author(s) -

Nattayaporn Apaiajai,

Titikorn Chunchai,

Thidarat Jaiwongkam,

Sasiwan Kerdphoo,

Siriporn C. Chattipakorn,

Nipon Chattipakorn

Publication year - 2018

Publication title -

gerontology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.397

H-Index - 94

eISSN - 1423-0003

pISSN - 0304-324X

DOI - 10.1159/000487188

Subject(s) - medicine , endocrinology , orchiectomy , testosterone (patch) , insulin resistance , insulin , cardiac function curve , mitochondrion , mitochondrial fusion , blood pressure , biology , heart failure , mitochondrial dna , gene , microbiology and biotechnology , biochemistry

We have previously reported that testosterone deprivation at a very young age accelerated, but did not aggravate, left-ventricular (LV) dysfunction in obese insulin-resistant rats. However, the effects of testosterone deprivation during adulthood on LV function in obese insulin-resistant rats remains unclear. We hypothesized that testosterone deprivation aggravates LV dysfunction and cardiac autonomic imbalance via the impairment of cardiac mitochondrial function and dynamics proteins, a reduction in insulin receptor function, and an increase in apoptosis in obese insulin-resistant rats.

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