Correlation Between Baseline Osteoprotegerin Serum Levels and Prognosis of Advanced-Stage Colorectal Cancer Patients | Zendy

Enrico de Toni | Zendy; Dorothea Nagel | Zendy; Alexander Philipp | Zendy; Andreas Herbst | Zendy; Isabel Thalhammer | Zendy; Julia Mayerle | Zendy; HelgaPaula Török | Zendy; Lydia Brandl | Zendy; Frank T. Kolligs | Zendy

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Correlation Between Baseline Osteoprotegerin Serum Levels and Prognosis of Advanced-Stage Colorectal Cancer Patients

Author(s) -

Enrico de Toni,

Dorothea Nagel,

Alexander Philipp,

Andreas Herbst,

Isabel Thalhammer,

Julia Mayerle,

HelgaPaula Török,

Lydia Brandl,

Frank T. Kolligs

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487101

Subject(s) - medicine , osteoprotegerin , carcinoembryonic antigen , colorectal cancer , immunohistochemistry , oncology , clinical significance , gastroenterology , cancer , receptor , activator (genetics)

Osteoprotegerin (OPG) is a soluble receptor of the pro-apoptotic cytokine TRAIL which is thought to contribute to tumour development by inhibiting apoptosis or affecting other aspects of tumour biology, including cell proliferation and immune response. Although immunohistochemical studies suggest that OPG correlates with survival in metastatic colorectal cancer (mCRC), only scarce data are available on serum OPG in CRC patients.

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