Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms | Zendy

Hannah Aucott | Zendy; Johan Lundberg | Zendy; Henna Salo | Zendy; Lena Klevenvall | Zendy; Peter Damberg | Zendy; Lars Ottosson | Zendy; Jan Andersson | Zendy; Staffan Holmin | Zendy; Helena Erlandsson Harris | Zendy

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Neuroinflammation in Response to Intracerebral Injections of Different HMGB1 Redox Isoforms

Author(s) -

Hannah Aucott,

Johan Lundberg,

Henna Salo,

Lena Klevenvall,

Peter Damberg,

Lars Ottosson,

Jan Andersson,

Staffan Holmin,

Helena Erlandsson Harris

Publication year - 2018

Publication title -

journal of innate immunity

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.078

H-Index - 64

eISSN - 1662-8128

pISSN - 1662-811X

DOI - 10.1159/000487056

Subject(s) - hmgb1 , neuroinflammation , proinflammatory cytokine , blood–brain barrier , microglia , lipopolysaccharide , central nervous system , inflammation , chemistry , medicine , pharmacology , immunology

Neuroinflammation triggered by infection or trauma is the cause of central nervous system dysfunction. High-mobility group box 1 protein (HMGB1), released from stressed and dying brain cells, is a potent neuroinflammatory mediator. The proinflammatory functions of HMGB1 are tightly regulated by post-translational redox modifications, and we here investigated detailed neuroinflammatory responses induced by the individual redox isoforms.

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