Increased Expression of the Innate Immune Receptor TLR10 in Obesity and Type-2 Diabetes: Association with ROS-Mediated Oxidative Stress | Zendy

Sardar Sindhu | Zendy; Nadeem Akhter | Zendy; Shihab Kochumon | Zendy; Reeby Thomas | Zendy; Ajit Wilson | Zendy; Steve Shenouda | Zendy; Jaakko Tuomilehto | Zendy; Rasheed Ahmad | Zendy

Open Access

Increased Expression of the Innate Immune Receptor TLR10 in Obesity and Type-2 Diabetes: Association with ROS-Mediated Oxidative Stress

Author(s) -

Sardar Sindhu,

Nadeem Akhter,

Shihab Kochumon,

Reeby Thomas,

Ajit Wilson,

Steve Shenouda,

Jaakko Tuomilehto,

Rasheed Ahmad

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000487034

Subject(s) - oxidative stress , adipose tissue , tlr2 , inflammation , biology , endocrinology , superoxide dismutase , medicine , adipose tissue macrophages , reactive oxygen species , tlr4 , immunology , microbiology and biotechnology , white adipose tissue

Metabolic diseases such as obesity and type-2 diabetes (T2D) are known to be associated with chronic low-grade inflammation called metabolic inflammation together with an oxidative stress milieu found in the expanding adipose tissue. The innate immune Toll-like receptors (TLR) such as TLR2 and TLR4 have emerged as key players in metabolic inflammation; nonetheless, TLR10 expression in the adipose tissue and its significance in obesity/T2D remain unclear.

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