Protective Effects of Let-7b on the Expression of Occludin by Targeting P38 MAPK in Preventing Intestinal Barrier Dysfunction | Zendy

Zhihua Liu | Zendy; Yinghai Tian | Zendy; Yanqiong Jiang | Zendy; Shihua Chen | Zendy; Ting Liu | Zendy; Mary Pat Moyer | Zendy; Huanlong Qin | Zendy; Xinke Zhou | Zendy

Open Access

Protective Effects of Let-7b on the Expression of Occludin by Targeting P38 MAPK in Preventing Intestinal Barrier Dysfunction

Author(s) -

Zhihua Liu,

Yinghai Tian,

Yanqiong Jiang,

Shihua Chen,

Ting Liu,

Mary Pat Moyer,

Huanlong Qin,

Xinke Zhou

Publication year - 2018

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486815

Subject(s) - occludin , barrier function , western blot , p38 mitogen activated protein kinases , tight junction , mapk/erk pathway , intestinal permeability , apoptosis , biology , medicine , andrology , microbiology and biotechnology , chemistry , immunology , cancer research , signal transduction , biochemistry , gene

Let-7b was dramatically reduced after a dicer knockout of mice with intestinal barrier function injuries. This paper aims to investigate the molecular mechanism of let-7b by targeting p38 MAPK in preventing intestinal barrier dysfunction.

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