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Objective:   In this study, the aim was to investigate the effect of hyoscine N-butylbromide (HnBB) pretreatment on pain during propofol injection.   Subjects and Methods:   In this prospective, randomized, placebo-controlled and double-blind trial, 60 patients scheduled to undergo routine outpatient surgery under general anesthesia were randomly allocated to 2 groups, the HnBB ( n  = 30) and sodium chloride ( n  = 30) groups. Twenty seconds after the injection of 20 mg HnBB or 0.9 % sodium chloride, a 50-mg dose of propofol was injected in 2–3 s. Ten seconds later, the pain intensity was assessed using a 4-point scale: no pain (0), mild (1), moderate (2), and severe (3) pain. The Student  t  test was used for the analysis of parametric data and the Pearson χ<sup>2</sup> test for categorical data.   Results:   The occurrence of pain in the HnBB group (43.3%) was significantly lower than the control group (73.3%) ( p  < 0.018). Of the 30 patients in each group, 10 in the control group and 3 in the HnBB group experienced severe pain ( p  = 0.001).   Conclusions:   Pretreatment with 20 mg HnBB significantly reduced propofol injection pain compared to placebo.

Hyoscine N-Butylbromide for Preventing Propofol Injection Pain: A Randomized, Placebo-Controlled and Double-Blind Study