Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis | Zendy

Feng Wang | Zendy; Jinyuan Tang | Zendy; Pengchao Li | Zendy; Shuhui Si | Zendy; Hao Yu | Zendy; Xiao Yang | Zendy; Jun Tao | Zendy; Qiang Lv | Zendy; Min Gu | Zendy; Haiwei Yang | Zendy; Zengjun Wang | Zendy

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Chloroquine Enhances the Radiosensitivity of Bladder Cancer Cells by Inhibiting Autophagy and Activating Apoptosis

Author(s) -

Feng Wang,

Jinyuan Tang,

Pengchao Li,

Shuhui Si,

Hao Yu,

Xiao Yang,

Jun Tao,

Qiang Lv,

Min Gu,

Haiwei Yang,

Zengjun Wang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486222

Subject(s) - autophagy , chloroquine , apoptosis , radiosensitivity , cancer research , clonogenic assay , biology , cancer cell , western blot , bladder cancer , carcinogenesis , chemistry , cancer , medicine , immunology , radiation therapy , biochemistry , genetics , malaria , gene

Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on autophagy inhibition and apoptosis induction.

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