Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study | Zendy

Mario Merlini | Zendy; Tunahan Kirabali | Zendy; Luka Kulic | Zendy; Roger M. Nitsch | Zendy; Maria Teresa Ferretti | Zendy

Open Access

Extravascular CD3+ T Cells in Brains of Alzheimer Disease Patients Correlate with Tau but Not with Amyloid Pathology: An Immunohistochemical Study

Author(s) -

Mario Merlini,

Tunahan Kirabali,

Luka Kulic,

Roger M. Nitsch,

Maria Teresa Ferretti

Publication year - 2018

Publication title -

neurodegenerative diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.98

H-Index - 57

eISSN - 1660-2862

pISSN - 1660-2854

DOI - 10.1159/000486200

Subject(s) - pathology , cd3 , amyloid (mycology) , amyloidosis , alzheimer's disease , immunohistochemistry , biology , medicine , cd8 , immune system , immunology , disease

Strong genetic and epidemiological evidence points to a crucial role of the immune system in the development of Alzheimer disease (AD). CD3+ T lymphocytes have been described in brains of postmortem AD patients and in transgenic models of AD-like cerebral amyloidosis and tau pathology. However, the occurrence of T cells in AD brains is still controversial; furthermore, the relationship between T cells and hallmarks of AD pathology (amyloid plaques and neurofibrillary tangles) remains to be established.

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