Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo | Zendy

Liyun Pan | Zendy; Yafeng Chen | Zendy; Hongchang Li | Zendy; Li-ming Bi | Zendy; Wenjie Sun | Zendy; Guifang Sun | Zendy; Xiaofen Zhang | Zendy; Ke Xu | Zendy; Dian-xu Feng | Zendy

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Dachengqi Decoction Attenuates Intestinal Vascular Endothelial Injury in Severe Acute Pancreatitis in Vitro and in Vivo

Author(s) -

Liyun Pan,

Yafeng Chen,

Hongchang Li,

Li-ming Bi,

Wenjie Sun,

Guifang Sun,

Xiaofen Zhang,

Ke Xu,

Dian-xu Feng

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486155

Subject(s) - evans blue , umbilical vein , acute pancreatitis , pharmacology , lipopolysaccharide , chemistry , proinflammatory cytokine , medicine , in vitro , inflammation , biochemistry

Dachengqi decoction (DCQD) is a well-known traditional Chinese herbal drug with strong anti-inflammatory effects. Angiopoietin-1 (Ang-1) plays a vital role in maintaining the stability and integrity of the vascular wall and prevents vascular leakage due to inflammatory mediators. Our previous work found that DCQD protects against pancreatic injury in rats with severe acute pancreatitis (SAP). This study aims to investigate the effects of DCQD on intestinal endothelial damage in both damaged human umbilical vein endothelial cells (HUVECs) and SAP rats.

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