Benzotriazole Enhances Cell Invasive Potency in Endometrial Carcinoma Through CTBP1-Mediated Epithelial-Mesenchymal Transition | Zendy

Yiquan Wang | Zendy; Chencheng Dai | Zendy; Cheng Zhou | Zendy; Wenqu Li | Zendy; Yujia Qian | Zendy; Juan Wen | Zendy; Yang Wang | Zendy; Bing Han | Zendy; Jingjing Ma | Zendy; Juan Xu | Zendy; Ziyi Fu | Zendy; Hongjie Ruan | Zendy; Hua Tong | Zendy; Xuemei Jia | Zendy

Open Access

Benzotriazole Enhances Cell Invasive Potency in Endometrial Carcinoma Through CTBP1-Mediated Epithelial-Mesenchymal Transition

Author(s) -

Yiquan Wang,

Chencheng Dai,

Cheng Zhou,

Wenqu Li,

Yujia Qian,

Juan Wen,

Yang Wang,

Bing Han,

Jingjing Ma,

Juan Xu,

Ziyi Fu,

Hongjie Ruan,

Hua Tong,

Xuemei Jia

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486123

Subject(s) - cancer research , viability assay , carcinoma , epithelial–mesenchymal transition , malignancy , gene silencing , biology , reverse transcription polymerase chain reaction , cell , cell growth , chemistry , cancer , gene expression , metastasis , gene , biochemistry , genetics

Benzotriazole (BTR) and its derivatives, such as intermediates and UV stabilizers, are important man-made organic chemicals found in everyday life that have been recently identified as environmental toxins and a threat to female reproductive health. Previous studies have shown that BTR could act as a carcinogen by mimicking estrogen. Environmental estrogen mimics could promote the initiation and development of female cancers, such as endometrial carcinoma, a type of estrogenic-sensitive malignancy. However, there is little information on the relationship between BTR and endometrial carcinoma. In this study, we aimed to demonstrate the biological function of BTR in endometrial carcinoma and explored the underlying mechanism.

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