The Role of Pannexin3-Modified Human Dental Pulp-Derived Mesenchymal Stromal Cells in Repairing Rat Cranial Critical-Sized Bone Defects | Zendy

Fangfang Song | Zendy; Hualing Sun | Zendy; Liyuan Huang | Zendy; Dongjie Fu | Zendy; Cui Huang | Zendy

Open Access

The Role of Pannexin3-Modified Human Dental Pulp-Derived Mesenchymal Stromal Cells in Repairing Rat Cranial Critical-Sized Bone Defects

Author(s) -

Fangfang Song,

Hualing Sun,

Liyuan Huang,

Dongjie Fu,

Cui Huang

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000486023

Subject(s) - wnt signaling pathway , microbiology and biotechnology , chemistry , mesenchymal stem cell , dental pulp stem cells , gene knockdown , downregulation and upregulation , western blot , signal transduction , biology , biochemistry , apoptosis , gene

Human dental pulp-derived mesenchymal stromal cells (hDPSCs) are promising seed cells for tissue engineering due to their easy accessibility and multi-lineage differentiation. Pannexin3 (Panx3) plays crucial roles during bone development and differentiation. The aim of the present study was to investigate the effect of Panx3 on osteogenesis of hDPSCs and the underlying mechanism.

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