YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways | Zendy

Haijun Li | Zendy; Fucheng He | Zendy; Xin Zhao | Zendy; Yuan Zhang | Zendy; Xi Chu | Zendy; Chunlan Hua | Zendy; Yunhui Qu | Zendy; Yu Duan | Zendy; Liang Ming | Zendy

Open Access

YAP Inhibits the Apoptosis and Migration of Human Rectal Cancer Cells via Suppression of JNK-Drp1-Mitochondrial Fission-HtrA2/Omi Pathways

Author(s) -

Haijun Li,

Fucheng He,

Xin Zhao,

Yuan Zhang,

Xi Chu,

Chunlan Hua,

Yunhui Qu,

Yu Duan,

Liang Ming

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485946

Subject(s) - microbiology and biotechnology , apoptosis , biology , hippo signaling pathway , mitochondrial fission , mitochondrion , signal transduction , cancer research , biochemistry

The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence is available concerning its role in cancer cell apoptosis and migration via mitochondrial homeostasis. Here, we identify mitochondrial fission as a regulator of the Hippo-Yap pathway in human rectal cancer tumorigenesis and metastasis.

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