SC1 Promotes MiR124-3p Expression to Maintain the Self-Renewal of Mouse Embryonic Stem Cells by Inhibiting the MEK/ERK Pathway | Zendy

Qing Wei | Zendy; Hongliang Liu | Zendy; Zhiying Ai | Zendy; Yongyan Wu | Zendy; Yingxiang Liu | Zendy; Zhaopeng Shi | Zendy; Xuexue Ren | Zendy; Zekun Guo | Zendy

Open Access

SC1 Promotes MiR124-3p Expression to Maintain the Self-Renewal of Mouse Embryonic Stem Cells by Inhibiting the MEK/ERK Pathway

Author(s) -

Qing Wei,

Hongliang Liu,

Zhiying Ai,

Yongyan Wu,

Yingxiang Liu,

Zhaopeng Shi,

Xuexue Ren,

Zekun Guo

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485945

Subject(s) - mapk/erk pathway , microbiology and biotechnology , embryonic stem cell , kegg , biology , microrna , retinoic acid , downregulation and upregulation , stem cell , cancer research , signal transduction , gene expression , transcriptome , cell culture , gene , genetics

Self-renewal is one of the most important features of embryonic stem (ES) cells. SC1 is a small molecule modulator that effectively maintains the self-renewal of mouse ES cells in the absence of leukemia inhibitory factor (LIF), serum and feeder cells. However, the mechanism by which SC1 maintains the undifferentiated state of mouse ES cells remains unclear.

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