FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells | Zendy

Qing Song | Zendy; Wenli Gou | Zendy; Yuliang Zou | Zendy

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FAM3A Protects Against Glutamate-Induced Toxicity by Preserving Calcium Homeostasis in Differentiated PC12 Cells

Author(s) -

Qing Song,

Wenli Gou,

Yuliang Zou

Publication year - 2017

Publication title -

cellular physiology and biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.486

H-Index - 87

eISSN - 1421-9778

pISSN - 1015-8987

DOI - 10.1159/000485943

Subject(s) - metabotropic glutamate receptor , ryanodine receptor , glutamate receptor , calcium in biology , inositol trisphosphate receptor , thapsigargin , fura 2 , microbiology and biotechnology , metabotropic glutamate receptor 1 , oxidative stress , chemistry , biology , intracellular , receptor , inositol , endocrinology , biochemistry , cytosol , enzyme

Stroke is the leading cause of adult disability, and glutamate-induced dysregulation of intracellular Ca2+ homeostasis is a key mechanism. FAM3A is the first member of the family with sequence similarity 3 (FAM3) gene family, and its biological function remains largely unknown. We have recently reported that FAM3A exerts protective effects against oxidative stress and mitochondrial dysfunction in HT22 cells.

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