The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production | Zendy

Fuqi Xu | Zendy; Shigang Qiao | Zendy; Hua Li | Zendy; Yanjun Deng | Zendy; Chen Wang | Zendy; Jianzhong An | Zendy

Open Access

The Effect of Mitochondrial Complex I-Linked Respiration by Isoflurane Is Independent of Mitochondrial Nitric Oxide Production

Author(s) -

Fuqi Xu,

Shigang Qiao,

Hua Li,

Yanjun Deng,

Chen Wang,

Jianzhong An

Publication year - 2018

Publication title -

cardiorenal medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.661

H-Index - 21

eISSN - 1664-3828

pISSN - 1664-5502

DOI - 10.1159/000485936

Subject(s) - respiration , isoflurane , nitric oxide , mitochondrion , chemistry , cellular respiration , biochemistry , endocrinology , biology , anatomy , organic chemistry

Anesthetic preconditioning (APC) of the myocardium is mediated in part by reversible alteration of mitochondrial function. Nitric oxide (NO) inhibits mitochondrial respiration and may mediate APC-induced cardioprotection. In this study, the effects of isoflurane on different states of mitochondrial respiration during the oxidation of complex I-linked substrates and the role of NO were investigated.

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